Working together with clients, we design studies and utilize approaches and tools that unequivocally guarantee the most scientifically accurate data. NeuroCog supports all stages of clinical trials from design through study implementation and interpretation of results. Below are links to some of the data we have presented based on our approach.

Cultural Adaptation of the Virtual Reality Functional Capacity Assessment Tool (VRFCAT) for Use in the UK and Canada

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The poster contains a discussion of methods for cross-cultural adaptation of performance-based outcome assessments: Cultural adaptation of performance-based outcomes can improve the quality of these assessments by ensuring tasks, stimuli and instructions are understood and appropriate for use in populations of interest; Use of culturally appropriate … Continued

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Rasch Analysis to Test the Cross-Cultural Item Equivalence of the Alzheimer’s Disease Assessment Scale – Cognitive (ADAS-Cog)

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Poster: Rasch Analysis to Test the Cross-Cultural Item Equivalence of the Alzheimer’s Disease Assessment Scale – Cognitive (ADAS-Cog) Introduction: Bias is a significant challenge to the validity of cognitive tests. Differential item functioning (DIF) is present when different groups have differing responses on test items, after … Continued

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Assessing the Impact of Centralized Data Review on the Reliability of the Alzheimer’s Disease Assessment Scale-Cognitive (ADAS-Cog)

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The Alzheimer’s Disease Assessment Scale Cognitive Subscale (ADAS-Cog) is the primary neurocognitive outcome measure in many clinical trials for mild-moderate Alzheimer’s disease (AD). Despite wide use, variations in administration and scoring are well-documented, and may reduce reliability and sensitivity of the measure. Variations in administration … Continued

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Implementing Neurocognitive Testing in Clinical Trials: Facilitating Rater Administration with an iPad-based App

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To facilitate rater administration of neurocognitive testing in clinical trials, we developed an iPad-based application (BAC App) of a widely used pen-and-paper battery, the Brief Assessment of Cognition (BAC). The purpose of the BAC App is to reduce administration burden on site raters by automating … Continued

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